… Resistance to anti-cancer treatments is a critical and … spectrum of patients with advanced
colorectal cancer (CRC) tend … , rendering cancer cells insensitive to the treatment of anti-cancer …

… on the cell signaling cross-talk mechanisms of colorectal cancer (CRC) … These interlinked
signals cross-talk with one another in various … for signal transduction application involving in …

… in cancer treatment by natural products are MAPK, PI3K/Akt, and NF- κB [4], [5]. Notably, it has
been observed that signal transducer … Breast cancer, colorectal cancer, gastric cancer, and …

… signal transduction during tumorigenesis is still not fully understood. In fact, recent studies
from our laboratory showed that TNF-β signaling … and malignancy of colon cancer cells. …

… It has been shown that TGF-β, via its signal transducer Smad protein that is associated
with TGF-β receptor, induces expression of high mobility group A2 (HMGA2) protein which …

… signaling is involved in regulating CRC cell proliferation as well. This research indicated that
signal transducers … and its down streams through PTEN/AKT signaling pathway [85]. The …

… STAT1 is one of the seven mammalian members of the signal transducer and activator of
the transcription (STAT) family. STAT1 plays an essential role in the immune response and …

… the PI3K/GSK3β/β-catenin (a cross-talk between the PI3K/Akt and Wnt/β-catenin
canonical … via signal transducer and activator of transcription protein 3 (STAT3) activation [88]. …

… The major cause of colorectal cancer (CRC) related mortality is due to its metastasis. Signaling
… Lipid metabolism has an indispensable influence on Shh signal transduction. Lipids can …

… bivalent state and contributes to the maintenance of colorectal cancer-initiating cells [54,
56]… of DCs through the signal transducer and activator of transcription 3 (STAT3) signaling …